Issue 8, 2007
From the journal:

Organic & Biomolecular Chemistry

Syntheses and anti-HIV activities of (±)-norcarbovir and (±)-norabacavir

Weiqiang Huang,a   Marvin J. Miller,*ab   Erik De Clercqc  and  Jan Balzarinic  

* Corresponding authors

a Department of Chemistry & Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana, USA
E-mail: mmiller1@nd.edu
Fax: +1 574 631 6652
Tel: +1 574 631 7571

b Leibniz Institute for Natural Products Research and Infection Biology-Hans Knoell Institute, Beutenbergstrasse 11a, Jena, Germany

c Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium

Abstract

Norcarbovir (1) and norabacavir (2), the desmethylene derivatives of anti-HIV agents carbovir and abacavir, were efficiently synthesized from a common intermediate 4. Their antitumor and antiviral activities were evaluated and the results indicate norabacavir showed comparable anti-HIV activity to that of abacavir.

Graphical abstract: Syntheses and anti-HIV activities of (±)-norcarbovir and (±)-norabacavir

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Article information

DOI
https://doi.org/10.1039/B700321H
Article type
Communication
Submitted
09 Jan 2007
Accepted
14 Feb 2007
First published
01 Mar 2007

Org. Biomol. Chem., 2007,5, 1164-1166

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Syntheses and anti-HIV activities of (±)-norcarbovir and (±)-norabacavir

W. Huang, M. J. Miller, E. De Clercq and J. Balzarini, Org. Biomol. Chem., 2007, 5, 1164 DOI: 10.1039/B700321H

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