Issue 2, 2007
From the journal:

Organic & Biomolecular Chemistry

A concise and convergent (formal) total synthesis of huperzine A†

Cathal Lucey,a   Sean A. Kellya  and  John Mann*a  

* Corresponding authors

a School of Chemistry, Queen's University Belfast, Stranmillis Road, Belfast, UK
E-mail: j.mann@qub.ac.uk
Fax: +44 (0)28 9097 4890
Tel: +44 (0)28 9097 5525

Abstract

The first convergent synthesis of the tricyclic skeleton of huperzine A is described and includes, as the key step, an efficient regioselective intramolecular Heck reaction of 2-(tert-butyldimethylsilyloxymethyl)-6-(2-methoxy-5-bromopyridin-6-yl)methylcyclohex-2-enol.

Graphical abstract: A concise and convergent (formal) total synthesis of huperzine A

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DOI
https://doi.org/10.1039/B615059D
Article type
Paper
Submitted
16 Oct 2006
Accepted
16 Nov 2006
First published
30 Nov 2006

Org. Biomol. Chem., 2007,5, 301-306

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A concise and convergent (formal) total synthesis of huperzine A

C. Lucey, S. A. Kelly and J. Mann, Org. Biomol. Chem., 2007, 5, 301 DOI: 10.1039/B615059D

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