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Issue 6, 2007
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Enzymatic synthesis of cyclic triterpenes

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Abstract

Covering: 2002 to 2006

This review covers recent advances in the chemistry and enzymology of squalenecyclase and oxidosqualene cyclase. The enzymatic cyclizations of squalene and oxidosqualene are the most remarkable steps in the biosynthesis of sterols and triterpenes. The polyenes are converted to various polycyclic triterpenes by different enzyme systems employing only small modification of the active-site. Recent crystallographic and structure-based mutagenesis studies as well as utilization of chemically synthesized active-site probes have begun to reveal intimate structural details of the enzyme-templated cyclization reactions. 126 References are cited.

Graphical abstract: Enzymatic synthesis of cyclic triterpenes

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Publication details

The article was received on 29 Jun 2007 and first published on 07 Aug 2007


Article type: Review Article
DOI: 10.1039/B616857B
Citation: Nat. Prod. Rep., 2007,24, 1311-1331

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    Enzymatic synthesis of cyclic triterpenes

    I. Abe, Nat. Prod. Rep., 2007, 24, 1311
    DOI: 10.1039/B616857B

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