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Issue 6, 2007
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Cellular targets of natural products

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Covering: 2001 to 2006 inclusive

Natural products have evolved, at least in part, to bind to biological macromolecules, particularly proteins. As a result, natural products are able to interact with many specific targets within the cell. Indeed for many years this has been central in the drug development process. Today, however, natural products are finding increasing use as probes to interrogate biological systems as part of chemical genomics and related research. In order to demonstrate the utility of natural products in these efforts, the biological activities of many of the major classes of natural products is discussed, according to the cellular organelle and localisation of their specific molecular targets. Emphasis is given to newly discovered compounds and activities that either provide interesting insights into a specific biological function, or that form the basis for potentially new therapeutic approaches.

Graphical abstract: Cellular targets of natural products

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Article information

12 Jun 2007
First published
17 Oct 2007

Nat. Prod. Rep., 2007,24, 1288-1310
Article type
Review Article

Cellular targets of natural products

N. Dixon, L. S. Wong, T. H. Geerlings and J. Micklefield, Nat. Prod. Rep., 2007, 24, 1288
DOI: 10.1039/B616808F

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