Issue 48, 2007

Enantioselective organocatalytic substitution of α-cyanoacetates on imidoyl chlorides – synthesis of optically active ketimines

Abstract

The enantioselective substitution of α-cyanoacetates on imidoyl chlorides under phase-transfer catalytic conditions is presented; a simple quinidine-derived phase-transfer catalyst gives access to the products, highly substituted ketimines, in generally good yields and up to 90% ee.

Graphical abstract: Enantioselective organocatalytic substitution of α-cyanoacetates on imidoyl chlorides – synthesis of optically active ketimines

Supplementary files

Article information

Article type
Communication
Submitted
12 Oct 2007
Accepted
07 Nov 2007
First published
16 Nov 2007

Chem. Commun., 2007, 5155-5157

Enantioselective organocatalytic substitution of α-cyanoacetates on imidoyl chlorides – synthesis of optically active ketimines

S. Santoro, T. B. Poulsen and K. A. Jørgensen, Chem. Commun., 2007, 5155 DOI: 10.1039/B715810F

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