Issue 27, 2007
From the journal:

Chemical Communications

Structurally-defined direct C-magnesiation and C-zincation of N-heterocyclic aromatic compounds using alkali-metal-mediated metallation†

Ben Conway,a   Eva Hevia,*a   Alan R. Kennedya  and  Robert E. Mulvey*a  

* Corresponding authors

a WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK
E-mail: r.e.mulvey@strath.ac.uk

Abstract

Demonstrating direct synergic “low polarity metallation”, 1-methylindole is C-magnesiated by (TMEDA)2·Na2MgBu4 and C-zincated by (TMEDA)·Na(tBu)(TMP)Zn(tBu), and 1-methylpyrrole is C-zincated by the same reagent, with all three metal products successfully crystallographically characterised.

Graphical abstract: Structurally-defined direct C-magnesiation and C-zincation of N-heterocyclic aromatic compounds using alkali-metal-mediated metallation

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B704362G
Article type
Communication
Submitted
22 Mar 2007
Accepted
24 Apr 2007
First published
04 May 2007

Chem. Commun., 2007, 2864-2866

Permissions

Request permissions

Structurally-defined direct C-magnesiation and C-zincation of N-heterocyclic aromatic compounds using alkali-metal-mediated metallation

B. Conway, E. Hevia, A. R. Kennedy and R. E. Mulvey, Chem. Commun., 2007, 2864 DOI: 10.1039/B704362G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements