Issue 23, 2007

Synthesis and reactivity of [18F]-N-fluorobenzenesulfonimide

Abstract

A novel [18F]NF reagent and two novel radiochemical transformations have been developed: [18F]NFSi has been prepared from sodium dibenzenesulfonimide and reacted in the presence of silyl enol ethers and allylsilanes to deliver labelled fluorinated ketones and allylic fluorides respectively; the radiosynthesis of the fluorinated A ring of vitamin D3 has also been completed with success.

Graphical abstract: Synthesis and reactivity of [18F]-N-fluorobenzenesulfonimide

Supplementary files

Article information

Article type
Communication
Submitted
25 Jan 2007
Accepted
23 Feb 2007
First published
14 Mar 2007

Chem. Commun., 2007, 2330-2332

Synthesis and reactivity of [18F]-N-fluorobenzenesulfonimide

H. Teare, E. G. Robins, E. Årstad, S. K. Luthra and V. Gouverneur, Chem. Commun., 2007, 2330 DOI: 10.1039/B701177F

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