Enantiopure 20(S)-camptothecin has been prepared from a known hydroxypyridone through a novel approach that involves a Claisen rearrangement, an asymmetric nucleophilic ethylation, a Heck coupling and a Friedländer condensation as the key transformations.
C. Tang, M. Babjak, R. J. Anderson, A. E. Greene and A. Kanazawa, Org. Biomol. Chem., 2006, 4, 3757 DOI: 10.1039/B611202A
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