Jump to main content
Jump to site search

Issue 38, 2006
Previous Article Next Article

Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis

Author affiliations

Abstract

The biosynthetic pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde (MBC), a key intermediate in the biosynthesis of prodiginine antibiotics in Streptomyces coelicolor, has been elucidated using a combination of gene replacements and feeding experiments with chemically synthesised MBC and a synthetic analogue of a pathway intermediate.

Graphical abstract: Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Jul 2006, accepted on 29 Aug 2006 and first published on 11 Sep 2006


Article type: Communication
DOI: 10.1039/B609556A
Chem. Commun., 2006, 3981-3983

  •   Request permissions

    Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis

    A. E. Stanley, L. J. Walton, M. Kourdi Zerikly, C. Corre and G. L. Challis, Chem. Commun., 2006, 3981
    DOI: 10.1039/B609556A

Search articles by author

Spotlight

Advertisements