Issue 23, 2006
From the journal:

Chemical Communications

Direct detection of nucleotide radical cations produced by electron-transfer oxidation of DNA bases with electron-transfer state of 9-mesityl-10-methylacridinium ion and resulting efficient DNA cleavage without oxygen†

Kei Ohkubo,a   Kazusa Yukimotoa  and  Shunichi Fukuzumi*a  

* Corresponding authors

a Department of Material and Life Science, Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency (JST), Suita, Osaka, Japan
E-mail: fukuzumi@chem.eng.osaka-u.ac.jp
Fax: +81-6-6879-7370
Tel: +81-6-6879-7368

Abstract

Photoinduced electron transfer of DNA as well as DNA bases with 9-mesityl-10-methylacridinium ion results in formation of all types of DNA base radical cations, which have been detected as the transient absorption spectra measurements, leading to efficient DNA cleavage in the absence of O2.

Graphical abstract: Direct detection of nucleotide radical cations produced by electron-transfer oxidation of DNA bases with electron-transfer state of 9-mesityl-10-methylacridinium ion and resulting efficient DNA cleavage without oxygen

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Article information

DOI
https://doi.org/10.1039/B601418F
Article type
Communication
Submitted
30 Jan 2006
Accepted
18 Apr 2006
First published
08 May 2006

Chem. Commun., 2006, 2504-2506

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Direct detection of nucleotide radical cations produced by electron-transfer oxidation of DNA bases with electron-transfer state of 9-mesityl-10-methylacridinium ion and resulting efficient DNA cleavage without oxygen

K. Ohkubo, K. Yukimoto and S. Fukuzumi, Chem. Commun., 2006, 2504 DOI: 10.1039/B601418F

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