Issue 6, 2006
From the journal:

Chemical Communications

Chloride ion efflux from liposomes is controlled by sidechains in a channel-forming heptapeptide

Lei You,a   Riccardo Ferdanib  and  George W. Gokel*ab  

* Corresponding authors

a Department of Chemistry, Washington University, 1 Brookings Drive, St. Louis, USA

b Department of Molecular Biology & Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 S. Euclid Ave., St. Louis, USA
E-mail: ggokel@wustl.edu
Fax: +1 314/362-9298 or 7058
Tel: +1 314/362-9297

Abstract

A suite of amphiphilic heptapeptides incorporating a glutamic acid derivative on the C-terminal side of a (Gly)3Pro sequence gives dramatically lower chloride ion release from liposomes when present in free carboxyl form rather than as an ester or amide.

Graphical abstract: Chloride ion efflux from liposomes is controlled by sidechains in a channel-forming heptapeptide

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Article information

DOI
https://doi.org/10.1039/B517713H
Article type
Communication
Submitted
09 Sep 2005
Accepted
08 Dec 2005
First published
03 Jan 2006

Chem. Commun., 2006, 603-605

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Chloride ion efflux from liposomes is controlled by sidechains in a channel-forming heptapeptide

L. You, R. Ferdani and G. W. Gokel, Chem. Commun., 2006, 603 DOI: 10.1039/B517713H

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