Total synthesis of floresolide B and Δ6,7-Z-floresolide B

K. C. Nicolaou; Hao Xu

doi:10.1039/B517385J

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Total synthesis of floresolide B and Δ^6,7-Z-floresolide B†

K. C. Nicolaou*^ab and Hao Xu^a

Author affiliations

* Corresponding authors

^a Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
E-mail: kcn@scripps.edu

^b Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA

Abstract

The total syntheses of the cytotoxin marine natural product floresolide B (1) and its Δ^6,7-Z isomer (2) have been achieved through an olefin metathesis-based strategy.

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Article information

DOI: https://doi.org/10.1039/B517385J
Article type: Communication
Submitted: 07 Dec 2005
Accepted: 06 Jan 2006
First published: 20 Jan 2006

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Chem. Commun., 2006, 600-602

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Total synthesis of floresolide B and Δ^6,7-Z-floresolide B

K. C. Nicolaou and H. Xu, Chem. Commun., 2006, 600 DOI: 10.1039/B517385J

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