Issue 10, 2005
From the journal:

Organic & Biomolecular Chemistry

The synthesis of water soluble decalin-based thiols and S-nitrosothiols—model systems for studying the reactions of nitric oxide with proteinthiols

Alan C. Spivey,*a   Jacqueline Colley,b   Lindsey Sprigens,b   Susan M. Hancock,b   D. Stuart Cameron,b   Kordi I. Chigboh,a   Gemma Veitch,a   Christopher S. Framptonc  and  Harry Adamsb  

* Corresponding authors

a Department of Chemistry, Imperial College, South Kensington campus, London

b Department of Chemistry, University of Sheffield, Brook Hill, Sheffield

c Pharmorphix Ltd., 250 Cambridge Science Park, Milton Road, Cambridge

Abstract

The syntheses of three decalin-based tert-thiols displaying varying degrees of solubility in aqueous milieu are described. The S-nitroso derivatives of these compounds have also been prepared and the structures of two of these determined by single crystal X-ray diffraction. These compounds have been designed for studying the interaction of nitric oxide (NO) with thiols under physiological conditions.

Graphical abstract: The synthesis of water soluble decalin-based thiols and S-nitrosothiols—model systems for studying the reactions of nitric oxide with protein thiols

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Article information

DOI
https://doi.org/10.1039/B503758A
Article type
Paper
Submitted
14 Mar 2005
Accepted
05 Apr 2005
First published
19 Apr 2005

Org. Biomol. Chem., 2005,3, 1942-1952

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The synthesis of water soluble decalin-based thiols and S-nitrosothiols—model systems for studying the reactions of nitric oxide with protein thiols

A. C. Spivey, J. Colley, L. Sprigens, S. M. Hancock, D. S. Cameron, K. I. Chigboh, G. Veitch, C. S. Frampton and H. Adams, Org. Biomol. Chem., 2005, 3, 1942 DOI: 10.1039/B503758A

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