Issue 12, 2005
From the journal:

Organic & Biomolecular Chemistry

Tandem hydroformylation–hydrazone formation–Fischer indole synthesis: a novel approach to tryptamides†

Axel M. Schmidta  and  Peter Eilbracht*a  

* Corresponding authors

a Universität Dortmund, Fachbereich Chemie, Organische Chemie I, Otto-Hahn-Str. 6, 44227 Dortmund
E-mail: peter.eilbracht@udo.edu
Fax: 49-231-7555363
Tel: 49-231-7553858

Abstract

A novel one-pot synthesis of indole systems via tandem hydroformylation–hydrazone formation–Fischer indolization starting from allylic amides and aryl hydrazines is described. This tandem procedure directly leads to biologically interesting tryptamides and analogues.

Graphical abstract: Tandem hydroformylation–hydrazone formation–Fischer indole synthesis: a novel approach to tryptamides

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Article information

DOI
https://doi.org/10.1039/B503396A
Article type
Paper
Submitted
08 Mar 2005
Accepted
05 May 2005
First published
20 May 2005

Org. Biomol. Chem., 2005,3, 2333-2343

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Tandem hydroformylation–hydrazone formation–Fischer indole synthesis: a novel approach to tryptamides

A. M. Schmidt and P. Eilbracht, Org. Biomol. Chem., 2005, 3, 2333 DOI: 10.1039/B503396A

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