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Issue 6, 2005
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Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage ‘in cellulo

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Abstract

The synthesis and photophysical characterisation are reported of a series of cationic, neutral and anionic europium and terbium complexes based on structurally related, nonadentate ligands based on the cyclen macrocycle. Each complex incorporates a tetraazatriphenylene moiety and overall absolute emission quantum yields are in the range 15–40% in aerated aqueous media. Dynamic quenching of the lanthanide excited state occurs with electron-rich donors, e.g. iodide, ascorbate and urate, and a mechanistic interpretation is put forward involving an electron transfer process. The cationic lanthanide complexes are taken up by NlH/3T3 cells and tend to localise inside the cell nucleus.

Graphical abstract: Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage ‘in cellulo’

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Publication details

The article was received on 20 Dec 2004, accepted on 19 Jan 2005 and first published on 02 Mar 2005


Article type: Paper
DOI: 10.1039/B418964G
Org. Biomol. Chem., 2005,3, 1013-1024

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    Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage ‘in cellulo

    R. A. Poole, G. Bobba, M. J. Cann, J. Frias, D. Parker and R. D. Peacock, Org. Biomol. Chem., 2005, 3, 1013
    DOI: 10.1039/B418964G

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