Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Issue 2, 2005
Previous Article Next Article

Synthesis and biological evaluation of gramicidin S dimers

Author affiliations


The design and synthesis of analogues of the cyclic β-sheet peptide gramicidin S (GS), having additional functionalities in their turn regions, is reported. The monomeric GS analogues were transformed into dimers and their activities towards biological membranes, through antimicriobial and hemolytic assays, were evaluated. Finally, conductivity measurements have been performed to elucidate ion channel forming properties.

Graphical abstract: Synthesis and biological evaluation of gramicidin S dimers

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Sep 2004, accepted on 10 Nov 2004 and first published on 08 Dec 2004

Article type: Paper
DOI: 10.1039/B414618B
Citation: Org. Biomol. Chem., 2005,3, 233-238

  •   Request permissions

    Synthesis and biological evaluation of gramicidin S dimers

    G. M. Grotenbreg, M. D. Witte, P. A. V. van Hooft, E. Spalburg, P. Reiß, D. Noort, A. J. de Neeling, U. Koert, G. A. van der Marel, H. S. Overkleeft and M. Overhand, Org. Biomol. Chem., 2005, 3, 233
    DOI: 10.1039/B414618B

Search articles by author