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Issue 2, 2005
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Synthesis and biological evaluation of gramicidin S dimers

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Abstract

The design and synthesis of analogues of the cyclic β-sheet peptide gramicidin S (GS), having additional functionalities in their turn regions, is reported. The monomeric GS analogues were transformed into dimers and their activities towards biological membranes, through antimicriobial and hemolytic assays, were evaluated. Finally, conductivity measurements have been performed to elucidate ion channel forming properties.

Graphical abstract: Synthesis and biological evaluation of gramicidin S dimers

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Publication details

The article was received on 22 Sep 2004, accepted on 10 Nov 2004 and first published on 08 Dec 2004


Article type: Paper
DOI: 10.1039/B414618B
Citation: Org. Biomol. Chem., 2005,3, 233-238

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    Synthesis and biological evaluation of gramicidin S dimers

    G. M. Grotenbreg, M. D. Witte, P. A. V. van Hooft, E. Spalburg, P. Reiß, D. Noort, A. J. de Neeling, U. Koert, G. A. van der Marel, H. S. Overkleeft and M. Overhand, Org. Biomol. Chem., 2005, 3, 233
    DOI: 10.1039/B414618B

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