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Issue 3, 2005
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5-Hydroxyuracil can form stable base pairs with all four bases in a DNA duplex

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Abstract

NMR studies, UV-monitored melting experiments, and ab initio calculations show that 5-hydroxyuracil, produced by the oxidative de-amination of cytosines by reactive oxygen species, can form stable base-pairs with dA, dG, dC and dT residues in a DNA duplex, providing a basis for the in-vivo incorporation of 5-hydroxyuracil during DNA replication.

Graphical abstract: 5-Hydroxyuracil can form stable base pairs with all four bases in a DNA duplex

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Publication details

The article was received on 21 Sep 2004, accepted on 12 Oct 2004 and first published on 30 Nov 2004


Article type: Communication
DOI: 10.1039/B414474K
Citation: Chem. Commun., 2005,0, 400-402
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    5-Hydroxyuracil can form stable base pairs with all four bases in a DNA duplex

    V. Thiviyanathan, A. Somasunderam, D. E. Volk and D. G. Gorenstein, Chem. Commun., 2005, 0, 400
    DOI: 10.1039/B414474K

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