Issue 44, 2005

Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates

Abstract

A range of pentafluorophenyl (PFP) sulfonate esters derived from the reaction of PFP vinyl sulfonate and various nitrones are shown to have significant inhibitory activity against the bacterial enzymes DDAH and ADI.

Graphical abstract: Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates

Article information

Article type
Communication
Submitted
27 Jul 2005
Accepted
16 Sep 2005
First published
11 Oct 2005

Chem. Commun., 2005, 5563-5565

Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates

P. Vallance, H. D. Bush, B. J. Mok, R. Hurtado-Guerrero, H. Gill, S. Rossiter, J. D. Wilden and S. Caddick, Chem. Commun., 2005, 5563 DOI: 10.1039/B510709A

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