Issue 44, 2005
From the journal:

Chemical Communications

Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates†

Patrick Vallance,*b   Hannah D. Bush,a   B. James Mok,a   Ramon Hurtado-Guerrero,b   Herpreet Gill,b   Sharon Rossiter,b   Jonathan D. Wildena  and  Stephen Caddick*a  

* Corresponding authors

a Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK
E-mail: s.caddick@ucl.ac.uk

b Department of Medicine, The Rayne Building, 5 University Street London, WC1E 6JJ, UK
E-mail: patrick.vallance@ucl.ac.uk

Abstract

A range of pentafluorophenyl (PFP) sulfonate esters derived from the reaction of PFP vinyl sulfonate and various nitrones are shown to have significant inhibitory activity against the bacterial enzymes DDAH and ADI.

Graphical abstract: Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates

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Article information

DOI
https://doi.org/10.1039/B510709A
Article type
Communication
Submitted
27 Jul 2005
Accepted
16 Sep 2005
First published
11 Oct 2005

Chem. Commun., 2005, 5563-5565

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Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates

P. Vallance, H. D. Bush, B. J. Mok, R. Hurtado-Guerrero, H. Gill, S. Rossiter, J. D. Wilden and S. Caddick, Chem. Commun., 2005, 5563 DOI: 10.1039/B510709A

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