Issue 20, 2005

Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus

Abstract

We isolated a novel unique pentaketide dimer designated as epoxytwinol A from the fermentation broth of a fungus. The structure of epoxytwinol A was determined to have a new carbon skeleton with C2 symmetry by elucidation of spectroscopic evidence. Epoxytwinol A inhibited endothelial cell migration stimulated by vascular endothelial growth factor (ED100 = 2.6 µM).

Graphical abstract: Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus

Article information

Article type
Communication
Submitted
27 Jan 2005
Accepted
03 Mar 2005
First published
15 Mar 2005

Chem. Commun., 2005, 2575-2577

Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus

H. Kakeya, R. Onose, H. Koshino and H. Osada, Chem. Commun., 2005, 2575 DOI: 10.1039/B501392E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements