Issue 20, 2005
From the journal:

Chemical Communications

Kinetic analysis of hydrolytic reaction of homo- and heterochiral adenylyl(3′–5′)adenosine isomers: breaking homochirality reduces hydrolytic stability of RNA†

Hidehito Urata,*a   Rie Sasaki,a   Hiroyo Morita,a   Marina Kusumoto,a   Yoko Ogawa,a   Kozue Mitsudaa  and  Masao Akagi*a  

* Corresponding authors

a Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, Japan
E-mail: urata@gly.oups.ac.jp
Fax: +81 (72) 690 1005
Tel: +81 (72) 690 1089

Abstract

The hydrolytic stability of the diastereomeric isomers of ApA was compared and the results show that heterochiral ApAs are more rapidly hydrolyzed than homochiral ApAs at low temperatures, suggesting that hydrolytic selection in cold environments in conjunction with selective polymerization may have been effective in enriching the homochirality of RNA.

Graphical abstract: Kinetic analysis of hydrolytic reaction of homo- and heterochiral adenylyl(3′–5′)adenosine isomers: breaking homochirality reduces hydrolytic stability of RNA

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Article information

DOI
https://doi.org/10.1039/B500673B
Article type
Communication
Submitted
14 Jan 2005
Accepted
08 Mar 2005
First published
18 Mar 2005

Chem. Commun., 2005, 2578-2580

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Kinetic analysis of hydrolytic reaction of homo- and heterochiral adenylyl(3′–5′)adenosine isomers: breaking homochirality reduces hydrolytic stability of RNA

H. Urata, R. Sasaki, H. Morita, M. Kusumoto, Y. Ogawa, K. Mitsuda and M. Akagi, Chem. Commun., 2005, 2578 DOI: 10.1039/B500673B

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