Jump to main content
Jump to site search

Issue 10, 2004
Previous Article Next Article

Aldehyde detection by chromogenic/fluorogenic oxime bond fragmentation

Author affiliations

Abstract

Amination of 4-nitrophenol, umbelliferone and 4-methylumbelliferone gave the corresponding oxyamines 1–3. These oxyamines react with aldehydes and ketones to form oximes. In the case of aliphatic aldehydes and electron-poor aromatic aldehydes, the oximes undergo base-catalyzed fragmentation in aqueous buffer in the presence of bovine serum albumin to give the parent phenols, which is the acyclic analog of Kemp's elimination reaction of 5-nitrobenzisoxazole 28. The process can be used as a spectrophotometric assay for formaldehyde under aqueous neutral conditions.

Graphical abstract: Aldehyde detection by chromogenic/fluorogenic oxime bond fragmentation

Back to tab navigation

Supplementary files

Article information


Submitted
09 Jan 2004
Accepted
18 Mar 2004
First published
15 Apr 2004

Org. Biomol. Chem., 2004,2, 1471-1475
Article type
Paper

Aldehyde detection by chromogenic/fluorogenic oxime bond fragmentation

S. Salahuddin, O. Renaudet and J. Reymond, Org. Biomol. Chem., 2004, 2, 1471
DOI: 10.1039/B400314D

Social activity

Search articles by author

Spotlight

Advertisements