Issue 17, 2004

On the preparation of ortho-trifluoromethyl phenyl triflate

Abstract

In contrast to an earlier report advocating a copper-mediated trifluoromethylation of ortho-iodophenyl triflate, ortho-trifluoromethyl phenyl triflate may be prepared simply by reacting the corresponding phenol with triflic anhydride in the presence of a nucleophilic catalyst and stoichiometric base.

Graphical abstract: On the preparation of ortho-trifluoromethyl phenyl triflate

Article information

Article type
Comment
Submitted
06 May 2004
Accepted
01 Jul 2004
First published
04 Aug 2004

Org. Biomol. Chem., 2004,2, 2547-2548

On the preparation of ortho-trifluoromethyl phenyl triflate

D. Gill, A. J. Hester and G. C. Lloyd-Jones, Org. Biomol. Chem., 2004, 2, 2547 DOI: 10.1039/B406803C

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