Issue 12, 2004
From the journal:

Organic & Biomolecular Chemistry

Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesis†

Gemma L. Thomas,a   Mark Ladlowb  and  David R. Spring*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: drspring@ch.cam.ac.uk

b GSK Cambridge Technology Centre, University of Cambridge, Lensfield Road, Cambridge, UK

Abstract

Bromopolystyrene beads with diameters of up to 600 µm have been derivatized completely, via bromine–magnesium exchange and interception with electrophiles, to yield high quality solid-supported reagents, scavengers and solid supports for use in diversity-oriented synthesis.

Graphical abstract: Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesis

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Article information

DOI
https://doi.org/10.1039/B406488G
Article type
Communication
Submitted
19 Feb 2004
Accepted
30 Apr 2004
First published
13 May 2004

Org. Biomol. Chem., 2004,2, 1679-1681

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Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesis

G. L. Thomas, M. Ladlow and D. R. Spring, Org. Biomol. Chem., 2004, 2, 1679 DOI: 10.1039/B406488G

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