Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 2, 2004
Previous Article Next Article

Anti-staphylococcal plant natural products

Author affiliations

Abstract

Covering: 1995 to 2003

The occurrence of vancomycin-resistant Staphylococcus aureus (VRSA) and multidrug-resistant (MDR) strains of this organism necessitate the discovery of new classes of anti-staphylococcal drug leads. At present there are no single chemical entity plant derived antibacterials used clinically, and this biologically diverse group deserves consideration as a source of chemical diversity for two important reasons. Firstly, plants have exceptional ability to produce cytotoxic agents and, secondly, there is an ecological rationale that antibacterial natural products should be present or synthesised de novo following microbial attack to protect plants from invasive and pathogenic microbes in their environment. This review cites plant natural products that either modify resistance in Staphylococcus aureus or are antibacterial through bacteriostatic or bactericidal properties. The activities described here show that there are many potential new classes of anti-staphylococcal agents which should undergo further cytotoxicity, microbial specificity and preclinical in vivo studies to assess their potential.

Graphical abstract: Anti-staphylococcal plant natural products

Back to tab navigation

Publication details

The article was received on 18 Dec 2003 and first published on 01 Mar 2004


Article type: Review Article
DOI: 10.1039/B212695H
Citation: Nat. Prod. Rep., 2004,21, 263-277

  •   Request permissions

    Anti-staphylococcal plant natural products

    S. Gibbons, Nat. Prod. Rep., 2004, 21, 263
    DOI: 10.1039/B212695H

Search articles by author

Spotlight

Advertisements