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Issue 2, 2004
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Fatty acid desaturases: selecting the dehydrogenation channel

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Abstract

Covering: 1958 to September 2003

Desaturation (O2-dependent dehydrogenation) of long chain fatty acyl derivatives is a ubiquitous biotransformation which generates a wide variety of oxidized lipidic natural products with important biological properties. Recent advances in molecular/structural biology coupled with the application of novel mechanistic probes have led to a more sophisticated understanding of how fatty acid desaturases function. In this review, the major milestones along the pathway of desaturase research will be highlighted from a bioorganic perspective. 178 references are cited.

Graphical abstract: Fatty acid desaturases: selecting the dehydrogenation channel

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Publication details

The article was received on 03 Nov 2003 and first published on 04 Mar 2004


Article type: Review Article
DOI: 10.1039/B302094K
Nat. Prod. Rep., 2004,21, 249-262

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    Fatty acid desaturases: selecting the dehydrogenation channel

    P. H. Buist, Nat. Prod. Rep., 2004, 21, 249
    DOI: 10.1039/B302094K

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