Issue 4, 2004

Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier

Abstract

A schizophyllan (β-1,3-glucan) derivative carrying lactose-appendages prepared by reductive amination can form stable macromolecular complexes with polynucleotides, shows excellent affinity with a lactose-binding lectin, and effectively mediates gene transfection into hepatocytes.

Graphical abstract: Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier

Supplementary files

Article information

Article type
Communication
Submitted
23 Oct 2003
Accepted
17 Dec 2003
First published
26 Jan 2004

Chem. Commun., 2004, 382-383

Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier

T. Hasegawa, M. Umeda, T. Matsumoto, M. Numata, M. Mizu, K. Koumoto, K. Sakurai and S. Shinkai, Chem. Commun., 2004, 382 DOI: 10.1039/B313426A

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