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Issue 24, 2003
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Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia™)

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Abstract

The commercially important antihyperglycemic agent Rosiglitazone 1 (Avandia™) has been prepared in high purity by a multi-step, polymer-assisted solution phase (PASP) synthesis without the need for the conventional chromatographic purification of any intermediates.

Graphical abstract: Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia™)

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Article information


Submitted
03 Jul 2003
Accepted
22 Oct 2003
First published
06 Nov 2003

Org. Biomol. Chem., 2003,1, 4392-4395
Article type
Paper

Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia™)

X. Li, C. Abell, B. H. Warrington and M. Ladlow, Org. Biomol. Chem., 2003, 1, 4392
DOI: 10.1039/B307549D

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