Issue 24, 2003
From the journal:

Organic & Biomolecular Chemistry

Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia™)†

Xin Li,a   Chris Abell,a   Brian H. Warringtonb  and  Mark Ladlow*b  

* Corresponding authors

a Department of Chemistry, University Chemical Laboratories, Lensfield Road, Cambridge, UK
Fax: +44 (0) 1223 336362
Tel: +44 (0) 1223 336405

b GlaxoSmithKline Cambridge Technology Centre, University Chemical Laboratory, Lensfield Road, Cambridge, UK
E-mail: Mark.2.Ladlow@gsk.com
Fax: +44 (0) 1223 331532
Tel: +44 (0) 1223 336349

Abstract

The commercially important antihyperglycemic agent Rosiglitazone 1 (Avandia™) has been prepared in high purity by a multi-step, polymer-assisted solution phase (PASP) synthesis without the need for the conventional chromatographic purification of any intermediates.

Graphical abstract: Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia™)

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Article information

DOI
https://doi.org/10.1039/B307549D
Article type
Paper
Submitted
03 Jul 2003
Accepted
22 Oct 2003
First published
06 Nov 2003

Org. Biomol. Chem., 2003,1, 4392-4395

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Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia™)

X. Li, C. Abell, B. H. Warrington and M. Ladlow, Org. Biomol. Chem., 2003, 1, 4392 DOI: 10.1039/B307549D

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