A facile synthesis of 1,4-benzothiazines under solvent free conditions
Abstract
A rapid, solvent free synthetic strategy for the oxidative cyclocondensation of 2-aminobenzenethiols and 1,3-dicarbonyls using a catalytic amount of hydrazine hydrate has been developed in order to obtain 2,3-disubstituted-1,4-benzothiazines in high yields (83–96%).