Issue 18, 2003
From the journal:

Chemical Communications

Asymmetric synthesis of α-aminoamides by Pd-catalyzed double carbohydroamination†

Perli Nanayakkaraa  and  Howard Alper*a  

* Corresponding authors

a Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, K1N 6N5, Canada
E-mail: halper@science.uottawa.ca
Fax: 613 562 5871
Tel: 613 562 5189

Abstract

Tris(dibenzylideneacetone)dipalladium(0) [Pd2(dba)3] catalyzed asymmetric double carbohydroamination of iodoarenes in the presence of a chiral ligand (Trost ligand and Me-DuPHOS are most effective) is an excellent method for the chiral synthesis of α-aminoamides in up to 99% ee.

Graphical abstract: Asymmetric synthesis of α-aminoamides by Pd-catalyzed double carbohydroamination

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Article information

DOI
https://doi.org/10.1039/B306879J
Article type
Communication
Submitted
17 Jun 2003
Accepted
05 Aug 2003
First published
19 Aug 2003

Chem. Commun., 2003, 2384-2385

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Asymmetric synthesis of α-aminoamides by Pd-catalyzed double carbohydroamination

P. Nanayakkara and H. Alper, Chem. Commun., 2003, 2384 DOI: 10.1039/B306879J

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