Facile synthesis of 2-substituted ethyl 2-(2-amino-5-ethoxycarbonylthiazol-4-yl)ethanoates
Abstract
An easy and convenient synthesis of highly functionalized 2-aminothiazole derivatives is described. Ethyl 2-bromo-2-(2-amino-5-ethoxycarbonylthiazol-4-yl)ethanoate 4 was obtained by reaction of 2,4-dibromo-3-oxoglutarate with