Issue 3, 2002

Facile synthesis of disubstituted and spiro five-membered benzosultams mediated by TMSCl–NaI–MeCN reagent

Abstract

o-Lithiation of N-tert-butylbenzenesulfonamide followed by reaction with ketones gave carbinol sulfonamides, which underwent TMSCl–NaI–MeCN reagent mediated cyclization to afford 3,3-disubstituted and spiro-2,3-dihydrobenzo[d]isothiazole-1,1-diones in high yields.

Graphical abstract: Facile synthesis of disubstituted and spiro five-membered benzosultams mediated by TMSCl–NaI–MeCN reagent

Article information

Article type
Communication
Submitted
29 Oct 2001
Accepted
21 Dec 2001
First published
10 Jan 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 302-303

Facile synthesis of disubstituted and spiro five-membered benzosultams mediated by TMSCl–NaI–MeCN reagent

Z. Liu, N. Shibata and Y. Takeuchi, J. Chem. Soc., Perkin Trans. 1, 2002, 302 DOI: 10.1039/B109832B

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