Issue 20, 2002
From the journal:

Chemical Communications

One-pot synthesis of hydrogen phosphonate derivatives of d4T and AZT

Xiao Bin Sun,a   Jian Xun Kangb  and  Yu Fen Zhao*a  

* Corresponding authors

a The Key Laboratory of Bio-organic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Science and Engineering, Tsinghua University, Beijing 100084, China
E-mail: tp-dch@mail.tsinghua.edu.cn
Fax: 86 10 6278 1695
Tel: 86 10 6277 2259

b Department of Chemistry, Zhengzhou University, Zhengzhou, Henan 450052, China

Abstract

A simple and one-pot route for the synthesis of d4T or AZT hydrogen phosphonate derivatives via reaction of d4T or AZT with phosphorus trichloride, then alcoholysis and dealkylation in the presence of the corresponding alcohol is described.

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Article information

DOI
https://doi.org/10.1039/B207657H
Article type
Communication
Submitted
06 Aug 2002
Accepted
29 Aug 2002
First published
20 Sep 2002

Chem. Commun., 2002, 2414-2415

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One-pot synthesis of hydrogen phosphonate derivatives of d4T and AZT

X. Bin Sun, J. Xun Kang and Y. Fen Zhao, Chem. Commun., 2002, 2414 DOI: 10.1039/B207657H

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