Issue 16, 2002
From the journal:

Chemical Communications

Novel synthesis of fused isoxazolidines via a palladium catalysed allene insertion–intramolecular 1,3-dipolar cycloaddition cascade reaction

Tajassas Aftab,a   Ronald Grigg,*a   Mark Ladlow,b   Visuvanathar Sridharana  and  Mark Thornton-Petta  

* Corresponding authors

a Molecular Innovation, Diversity and Automated Synthesis (MIDAS) Centre, School of Chemistry, Leeds University, Leeds, UK

b GlaxoSmithkline, Cambridge Chemistry Unit, Lensfield Road, Cambridge, UK

Abstract

A one pot, three component palladium catalysed allenation of aryl iodides, in combination with a nitrone cycloaddition, leads to formation of fused isoxazolidines, creating two rings, two stereocentres and one tetrasubstituted carbon centre.

Graphical abstract: Novel synthesis of fused isoxazolidines via a palladium catalysed allene insertion–intramolecular 1,3-dipolar cycloaddition cascade reaction

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Article information

DOI
https://doi.org/10.1039/B205069B
Article type
Communication
Submitted
27 May 2002
Accepted
02 Jul 2002
First published
11 Jul 2002

Chem. Commun., 2002, 1754-1755

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Novel synthesis of fused isoxazolidines via a palladium catalysed allene insertion–intramolecular 1,3-dipolar cycloaddition cascade reaction

T. Aftab, R. Grigg, M. Ladlow, V. Sridharan and M. Thornton-Pett, Chem. Commun., 2002, 1754 DOI: 10.1039/B205069B

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