Issue 6, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 2

5-Carboxy-5-methyl-1-pyrroline N-oxide: a spin trap for the hydroxyl radical

Pei Tsai,a   Martyna Elas,†b   Adrian D. Parasca,b   Eugene D. Barth,bc   Colin Mailer,bc   Howard J. Halpernbc  and  Gerald M. Rosen*acd  

* Corresponding authors

a Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, USA

b Department of Radiation and Cellular Oncology, University of Chicago, Chicago, USA

c Center for Low Frequency EPR for In Vivo Physiology, University of Chicago, Baltimore, USA, USA

d Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, USA

Abstract

The in vivo in situ detection of hydroxyl radical (HO˙) in real time has been one of the great challenges of free radicals in biology. While we have been able to identify this free radical as a secondary biomarker of HO˙, the discovery that 5-carboxy-5-methyl-1-pyrroline N-oxide 2 can specifically spin trap HO˙ at the expense of superoxide (O2˙−) opens new avenues of research. In particular, nitrone 2 will allow us to detect HO˙ from low doses of radiation in animal tumors in real time.

Graphical abstract: 5-Carboxy-5-methyl-1-pyrroline N-oxide: a spin trap for the hydroxyl radical

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Article information

DOI
https://doi.org/10.1039/B101945G
Article type
Paper
Submitted
01 Mar 2001
Accepted
05 Apr 2001
First published
01 May 2001

J. Chem. Soc., Perkin Trans. 2, 2001, 875-880

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5-Carboxy-5-methyl-1-pyrroline N-oxide: a spin trap for the hydroxyl radical

P. Tsai, M. Elas, A. D. Parasca, E. D. Barth, C. Mailer, H. J. Halpern and G. M. Rosen, J. Chem. Soc., Perkin Trans. 2, 2001, 875 DOI: 10.1039/B101945G

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