Issue 16, 2001

A concise and efficient stereoselective synthesis of protected (2R,1′S,2′S)-2-(carboxycyclopropyl)glycine (D-CCG-I)

Abstract

The stereoselective synthesis of protected D-carboxycyclopropylglycine (D-CCG-I) was achieved, as an extension of Taguchi's protocol for Simmons–Smith cyclopropanation to a chiral, amino-containing allyl alcohol derivative, in 8 steps (40% overall yield).

Graphical abstract: A concise and efficient stereoselective synthesis of protected (2R,1′S,2′S)-2-(carboxycyclopropyl)glycine (D-CCG-I)

Article information

Article type
Communication
Submitted
22 Jun 2001
Accepted
06 Jul 2001
First published
20 Jul 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 1851-1852

A concise and efficient stereoselective synthesis of protected (2R,1′S,2′S)-2-(carboxycyclopropyl)glycine (D-CCG-I)

D. K. Mohapatra, J. Chem. Soc., Perkin Trans. 1, 2001, 1851 DOI: 10.1039/B105503H

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