A concise and efficient stereoselective synthesis of protected (2R,1′S,2′S)-2-(carboxycyclopropyl)glycine (D-CCG-I)
Abstract
The stereoselective synthesis of protected D-carboxycyclopropylglycine (D-CCG-I) was achieved, as an extension of Taguchi's protocol for Simmons–Smith cyclopropanation to a chiral, amino-containing allyl alcohol derivative, in 8 steps (40% overall yield).