Issue 16, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Synthesis of 2-heteroaryl-3-hydroxypyridines by ring expansion reactions of 2-acylfurans with ammonia

Richard W. J. Chubb,a   Martin R. Bryce*a  and  Brian Tarbitb  

* Corresponding authors

a Department of Chemistry, University of Durham, Durham, UK
E-mail: m.r.bryce@durham.ac.uk

b Seal Sands Chemicals Ltd., Seal Sands Road, Seal Sands, Middlesbrough, UK

Abstract

A straightforward and versatile synthesis of 2-heteroaryl-3-hydroxypyridine derivatives is described by the one-step reaction of 2-acylfurans with ammonia at 150 °C.

Graphical abstract: Synthesis of 2-heteroaryl-3-hydroxypyridines by ring expansion reactions of 2-acylfurans with ammonia

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Article information

DOI
https://doi.org/10.1039/B105228B
Article type
Communication
Submitted
14 Jun 2001
Accepted
09 Jul 2001
First published
19 Jul 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 1853-1854

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Synthesis of 2-heteroaryl-3-hydroxypyridines by ring expansion reactions of 2-acylfurans with ammonia

R. W. J. Chubb, M. R. Bryce and B. Tarbit, J. Chem. Soc., Perkin Trans. 1, 2001, 1853 DOI: 10.1039/B105228B

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