Issue 19, 2001

A practical protocol for the synthesis of 3-hydroxy-4,5-disubstituted pyridine derivatives from acyclic compounds

Abstract

The paper reports a simple protocol for assembling a 3-hydroxy-4,5-disubstituted pyridine ring by reaction of allylamine or benzylamine and an α-bromo ketone and successive N-dealkylation.

Graphical abstract: A practical protocol for the synthesis of 3-hydroxy-4,5-disubstituted pyridine derivatives from acyclic compounds

Article information

Article type
Paper
Submitted
04 Jun 2001
Accepted
24 Jul 2001
First published
11 Sep 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 2404-2408

A practical protocol for the synthesis of 3-hydroxy-4,5-disubstituted pyridine derivatives from acyclic compounds

L. Anastasia, M. Anastasia and P. Allevi, J. Chem. Soc., Perkin Trans. 1, 2001, 2404 DOI: 10.1039/B105478N

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