Issue 17, 2001
From the journal:

Chemical Communications

Disruption of protein–protein interactions: design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase

Yen Wei,*a   George L. McLendon,*a   Andrew D. Hamilton,*c   Martin A. Case,a   Cherie B. Purring,a   Qing Lin,c   Hyung Soon Park,c   Chang-Sun Leec  and  Tianning Yua  

* Corresponding authors

a Department of Chemistry, Princeton University, Princeton, New Jersey, USA.
E-mail: glm@princeton.edu;
Fax: 609-258-6746;
Tel: 609-258-1595

b Department of Chemistry, Drexel University, Philadelphia, Pennsylvania, USA.
E-mail: weiyen@drexel.edu;
Fax: 215-895-1265;
Tel: 215-895-2650

c Department of Chemistry, Yale University, New Haven, Connecticut, USA.
E-mail: ahamilton@ursula.chem.yale.edu;
Fax: 203-432-3221;
Tel: 203-432-5570

Abstract

Synthetic receptor 1 has been found via fluorescence titration to compete effectively with cytochrome c peroxidase for binding cytochrome c (Cc), forming 1∶1 Cc∶1 complex with a binding constant of (3 ± 1) × 108 M−1, and to disrupt Cc∶Apaf-1 complex, a key adduct in apoptosis.

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Article information

DOI
https://doi.org/10.1039/B104142H
Article type
Communication
Submitted
01 May 2001
Accepted
14 Jun 2001
First published
06 Aug 2001

Chem. Commun., 2001, 1580-1581

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Disruption of protein–protein interactions: design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase

Y. Wei, G. L. McLendon, A. D. Hamilton, M. A. Case, C. B. Purring, Q. Lin, H. S. Park, C. Lee and T. Yu, Chem. Commun., 2001, 1580 DOI: 10.1039/B104142H

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