Issue 11, 2001
From the journal:

Chemical Communications

The synthesis of peptides using micro reactorsElectronic supplementary information (ESI) available: schematic of a borosilicate glass micro reactor. See http://www.rsc.org/suppdata/cc/b1/b102125g/

Paul Watts,a   Charlotte Wiles,a   Stephen J. Haswell,*a   Esteban Pombo-Villarb  and  Peter Styringc  

* Corresponding authors

a Department of Chemistry, University of Hull, Cottingham Road, Hull, UK
E-mail: S.J.Haswell@chem.hull.ac.uk

b Nervous System Research, WSJ-386.07.15, Novartis Pharma Ltd., Basel, Switzerland

c Department of Chemical and Process Engineering, University of Sheffield, Mappin Street, Sheffield, UK

Abstract

We have demonstrated the first application of multi-step synthesis within a micro reactor and have shown that peptides may be prepared in quantitative yield in a period of 20 min, compared with batch reactions where only moderate yields (40–50%) were obtained in a 24 h period.

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Article information

DOI
https://doi.org/10.1039/B102125G
Article type
Communication
Submitted
06 Mar 2001
Accepted
19 Apr 2001
First published
15 May 2001

Chem. Commun., 2001, 990-991

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The synthesis of peptides using micro reactors

P. Watts, C. Wiles, S. J. Haswell, E. Pombo-Villar and P. Styring, Chem. Commun., 2001, 990 DOI: 10.1039/B102125G

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