Incubation of alcoholic solutions of benzoylacetonitrile, 1, with a suitable aqueous culture of C. lunata results in highly diastereo- and enantioselective reactions leading to α-alkyl β-hydroxy nitriles 3, which are easily reduced to the corresponding γ-amino alcohols 6.
V. Gotor, J. R. Dehli and F. Rebolledo, J. Chem. Soc., Perkin Trans. 1, 2000, 307 DOI: 10.1039/A909721J
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