Issue 3, 2000

Reductive amination of carboxylic acids and [11C]magnesium halide carboxylates

Abstract

The reductive amination of carboxylic acids was shown to be promoted by 2-chloropyridine hydrochloride (3 eq). It allowed the one-pot preparation of N-alkylamines in yields up to 93% from carboxylic acid (1 eq), amine (1 eq) and sodium borohydride (5 molar eq). The reaction, carried out with [11C]magnesium halide carboxylates (11C, β+, t1/2∶20 min), led to N-[11C]alkylamines in 20–25% radiochemical yields (decay corrected to the end of bombardment, 30 min preparation time from [11C]CO2). In this case, the addition of pyridinium salts led only to the corresponding [11C]carboxylic acids.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 2000, 311-316

Reductive amination of carboxylic acids and [11C]magnesium halide carboxylates

C. Perrio-Huard, C. Aubert and M. Lasne, J. Chem. Soc., Perkin Trans. 1, 2000, 311 DOI: 10.1039/A908991H

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