Issue 24, 2000
From the journal:

Journal of the Chemical Society, Dalton Transactions

A zinc thiolate species which mimics aspects of the chemistry of the Ada repair protein and matrix metalloproteinases: the synthesis, structure and reactivity of the tris(2-mercapto-1-phenylimidazolyl)hydroborato complex [TmPh]ZnSPh†

Brian M. Bridgewater,a   Tauqir Fillebeen,‡a   Richard A. Friesner*a  and  Gerard Parkin*a  

* Corresponding authors

a Department of Chemistry, Columbia University, New York, USA

Abstract

The tris(2-mercapto-1-phenylimidazolyl)hydroborato ligand, [TmPh], has been used to prepare the zinc phenylthiolate derivative, [TmPh]ZnSPh, which provides a good structural model for zinc enzymes that possess [Zn(Cys)4] motifs; furthermore, the reactivity of the thiolate linkage in [TmPh]ZnSPh mimics the chemistry of the Ada protein and the activation mechanism of matrix metalloproteinases.

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Article information

DOI
https://doi.org/10.1039/B007886G
Article type
Communication
Submitted
28 Sep 2000
Accepted
05 Oct 2000
First published
20 Nov 2000

J. Chem. Soc., Dalton Trans., 2000, 4494-4496

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A zinc thiolate species which mimics aspects of the chemistry of the Ada repair protein and matrix metalloproteinases: the synthesis, structure and reactivity of the tris(2-mercapto-1-phenylimidazolyl)hydroborato complex [TmPh]ZnSPh

B. M. Bridgewater, T. Fillebeen, R. A. Friesner and G. Parkin, J. Chem. Soc., Dalton Trans., 2000, 4494 DOI: 10.1039/B007886G

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