Issue 18, 2000
From the journal:

Chemical Communications

Short cuts toward forskolin synthesis: a pentacyclic approachCCDC 182/1719. See http://www.rsc.org/suppdata/cc/b0/b004515m/ for crystallographic files in .cif format.

Massoumé Leclaire,*a   Raymond Levet,a   Franck Ferreira,a   Paul-Henri Ducrotb  and  Jean-Yves Lallemand Louis Ricardc  

* Corresponding authors

a Laboratoire DCSO, École Polytechnique, 91128 Palaiseau Cedex, France.
E-mail: leclaire@poly.polytechnique.fr

b Unité de Phytopharmacie et Médiateurs Chimiques, INRA, Route de Saint-Cyr, 78026 Versailles Cedex, France

c Laboratoire DCPH, École Polytechnique, 91128, Palaiseau Cedex, France

Abstract

A practical synthetic route for the preparation of forskolin intermediate 20 is described. Previously reported lactone 3 was converted to 20 through intermediate 16. The main feature of this work lies in the formation and the cleavage of a tetracyclic intermediate for the stereochemical control in the formation of the tricyclic core of forskolin.

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Article information

DOI
https://doi.org/10.1039/B004515M
Article type
Communication
Submitted
06 Jun 2000
Accepted
11 Jul 2000
First published
25 Aug 2000

Chem. Commun., 2000, 1737-1738

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Short cuts toward forskolin synthesis: a pentacyclic approach

M. Leclaire, R. Levet, F. Ferreira, P. Ducrot and J. Lallemand Louis Ricard, Chem. Commun., 2000, 1737 DOI: 10.1039/B004515M

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