Issue 18, 2000

Chiral amine–silyl triflate complex mediated asymmetric intramolecular Michael–aldol reaction via a novel enantioselective enol silylation process

Abstract

An asymmetric intramolecular Michael–aldol reaction of a Cs symmetric ketone using chiral amine and silyl triflate is described as a new methodology of chiral induction; nonracemic tricyclic cyclobutanes were obtained from a 4-substituted cyclohexanone in high yields with moderate enantioselectivities in one step.

Article information

Article type
Communication
Submitted
31 May 2000
Accepted
01 Aug 2000
First published
25 Aug 2000

Chem. Commun., 2000, 1739-1740

Chiral amine–silyl triflate complex mediated asymmetric intramolecular Michael–aldol reaction via a novel enantioselective enol silylation process

K. Takasu, K. Misawa, M. Yamada, Y. Furuta, T. Taniguchi and M. Ihara, Chem. Commun., 2000, 1739 DOI: 10.1039/B004320F

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