Peptides with nucleobase moieties as a stabilizing factor for a two-stranded α-helix

Sachiko Matsumura; Akihiko Ueno; Hisakazu Mihara

doi:10.1039/B004318O

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Peptides

Sachiko Matsumura,^a Akihiko Ueno^a and Hisakazu Mihara*^a

Author affiliations

* Corresponding authors

^a Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta, Yokohama 226-8501, Japan.
E-mail: hmihara@bio.titech.ac.jp

^b Form and Function, PRESTO, Japan Science and Technology Corporation, Tokyo Institute of Technology, Nagatsuta, Yokohama 226-8501, Japan

Abstract

The designed α-helical coiled-coil peptides, which contain nucleobase moieties at the amino acid side chains, were found to take a stable α-helical form owing to the base-pair interaction.

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Article information

DOI: https://doi.org/10.1039/B004318O
Article type: Communication
Submitted: 31 May 2000
Accepted: 20 Jul 2000
First published: 09 Aug 2000

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Chem. Commun., 2000, 1615-1616

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