Issue 5, 2000

Flow injection spectroscopic analysis of model drugs using on-line UV-diode array, FT-infrared and 1H-nuclear magnetic resonance spectroscopy and time-of-flight mass spectrometry

Abstract

A prototype flow injection analysis (FIA) system for the characterisation of compounds via a combination of diode array UV, 1H NMR, FT-IR spectroscopy and time-of-flight (TOF) mass spectrometry has been investigated using a number of pharmaceuticals and related compounds as model compounds. This combination of spectrometers allowed the on-flow collection of UV, 1H NMR, IR and mass spectra together with atomic composition data, enabling almost complete structural characterisation to be performed. Practical detection limits with the current system were in the region of 50 μg, however, the use of state of the art spectrometers would result in a significant reduction in the amount of material required.

Article information

Article type
Paper
Submitted
25 Jan 2000
Accepted
24 Mar 2000
First published
10 Apr 2000

Analyst, 2000,125, 927-931

Flow injection spectroscopic analysis of model drugs using on-line UV-diode array, FT-infrared and 1H-nuclear magnetic resonance spectroscopy and time-of-flight mass spectrometry

D. Louden, A. Handley, S. Taylor, E. Lenz, S. Miller, I. D. Wilson and A. Sage, Analyst, 2000, 125, 927 DOI: 10.1039/B000696N

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