Issue 1, 1999

Optically active 2,2-dimethyl-1,3,4-triazabicyclo[4.1.0]heptan-5-one: synthesis, spontaneous resolution and absolute configurat

Abstract

Bicycle (±)-1 crystallises as a conglomerate (space group P21) and undergoes spontaneous resolution on crystallisation from chloroform or acetone (16–44% ee). The absolute configuration (S)-(–)-1 was determined by synthesis from (S)-Ser-OMe; mutarotation due to the partial conversion of 1 into the corresponding isopropylidene 4 was observed in MeOH solution.

Article information

Article type
Paper

Mendeleev Commun., 1999,9, 26-27

Optically active 2,2-dimethyl-1,3,4-triazabicyclo[4.1.0]heptan-5-one: synthesis, spontaneous resolution and absolute configurat

R. G. Kostyanovskii, P. E. Dormov, P. T. Trapencieris, B. Strumfs, G. K. Kadorkina, I. I. Chervin and I. Y. Kalvinsh, Mendeleev Commun., 1999, 9, 26 DOI: 10.1070/MC1999v009n01ABEH001047

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