A new pathway for the synthesis of 2-(1-hydroxyalkyl)- and 2-(1-arylaminoalkyl)-morpholines via reaction of α-hydroxy- or α-amino-alkylation of 3-morpholinones followed by reduction with LiAlH4 of the intermediate compounds into the target substituted morpholines is proposed.
A. Dobrev, L. Nechev, C. Ivanov and M. Bon, J. Chem. Res. (S), 1999, 188 DOI: 10.1039/A808423H
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