Regioselective modification of the sugar moiety in pyrimidine nucleosides via a 4′,5′-dehydro-2′,3′-anhydrouridine intermediate
Abstract
3′-Substituted pyrimidine nucleoside derivatives are obtained in moderate to high yields by the reactionof 1-(2′,3′-anhydro-5′-deoxy-4′,5′-didehydro-α-L-erythro-pentofuranosyl)uracil with nucleophiles without the formation of the corresponding 2′-adduct.