By the addition of metal ion-containing water, a marked enhancement of the enantioselectivity for the lipase-catalysed esterification of 2-(4-substituted-phenoxy)propionic acids in Pri2O was observed, the mechanism of which will be discussed briefly on the basis of the initial rate obtained for each enantiomer of the substrate.
T. Okamoto and S. Ueji, Chem. Commun., 1999, 939 DOI: 10.1039/A902255D
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